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Small Molecule Sequestration of the Intrinsically Disordered Protein, p27Kip1, Within Soluble Oligomers.
Iconaru, Luigi I; Das, Sourav; Nourse, Amanda; Shelat, Anang A; Zuo, Jian; Kriwacki, Richard W.
Afiliação
  • Iconaru LI; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Present address: Sanofi, Waltham, MA 02451, USA.
  • Das S; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Nourse A; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Molecular Interactions Analysis Shared Resource, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Shelat AA; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Zuo J; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA. Electronic address: jianzuo@creighton.edu.
  • Kriwacki RW; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center, Memphis, TN 38163, USA. Electronic address: richard.kriwacki@stjude.org.
J Mol Biol ; 433(18): 167120, 2021 09 03.
Article em En | MEDLINE | ID: mdl-34197833
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Inibidor de Quinase Dependente de Ciclina p27 / Bibliotecas de Moléculas Pequenas / Descoberta de Drogas / Proteínas Intrinsicamente Desordenadas Limite: Humans Idioma: En Revista: J Mol Biol Ano de publicação: 2021 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Inibidor de Quinase Dependente de Ciclina p27 / Bibliotecas de Moléculas Pequenas / Descoberta de Drogas / Proteínas Intrinsicamente Desordenadas Limite: Humans Idioma: En Revista: J Mol Biol Ano de publicação: 2021 Tipo de documento: Article