Peptide Triazole Thiol Irreversibly Inactivates Metastable HIV-1 Env by Accessing Conformational Triggers Intrinsic to Virus-Cell Entry.

Ang, Charles Gotuaco; Carter, Erik; Haftl, Ann; Zhang, Shiyu; Rashad, Adel A; Kutzler, Michele; Abrams, Cameron F; Chaiken, Irwin M

Ang, Charles Gotuaco; Carter, Erik; Haftl, Ann; Zhang, Shiyu; Rashad, Adel A; Kutzler, Michele; Abrams, Cameron F; Chaiken, Irwin M.

Afiliação

Ang CG; Department of Biochemistry and Molecular Biology, College of Medicine, Drexel University, Philadelphia, PA 19102, USA.
Carter E; School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA 19102, USA.
Haftl A; Department of Biochemistry and Molecular Biology, College of Medicine, Drexel University, Philadelphia, PA 19102, USA.
Zhang S; Departments of Medicine and Microbiology and Immunology, College of Medicine, Drexel University, Philadelphia, PA 19102, USA.
Rashad AA; Department of Biochemistry and Molecular Biology, College of Medicine, Drexel University, Philadelphia, PA 19102, USA.
Kutzler M; Department of Chemistry, College of Arts and Sciences, Drexel University, Philadelphia, PA 19102, USA.
Abrams CF; Department of Biochemistry and Molecular Biology, College of Medicine, Drexel University, Philadelphia, PA 19102, USA.
Chaiken IM; School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA 19102, USA.

Microorganisms ; 9(6)2021 Jun 12.

Article em En | MEDLINE | ID: mdl-34204725

Palavras-chave

6-helix bundle; Env; HIV-1; MPER; entry inhibition; flow cytometry; membrane poration; metastability; peptide triazole

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 4_TD Base de dados: MEDLINE Idioma: En Revista: Microorganisms Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google