Bridging Cyanobacteria to Neurodegenerative Diseases: A New Potential Source of Bioactive Compounds against Alzheimer's Disease.
Mar Drugs
; 19(6)2021 Jun 16.
Article
em En
| MEDLINE
| ID: mdl-34208482
ABSTRACT
Neurodegenerative diseases (NDs) represent a drawback in society given the ageing population. Dementias are the most prevalent NDs, with Alzheimer's disease (AD) representing around 70% of all cases. The current pharmaceuticals for AD are symptomatic and with no effects on the progression of the disease. Thus, research on molecules with therapeutic relevance has become a major focus for the scientific community. Cyanobacteria are a group of photosynthetic prokaryotes rich in biomolecules with confirmed activity in pathologies such as cancer, and with feasible potential in NDs such as AD. In this review, we aimed to compile the research works focused in the anti-AD potential of cyanobacteria, namely regarding the inhibition of the enzyme ß-secretase (BACE1) as a fundamental enzyme in the generation of ß-amyloid (Aß), the inhibition of the enzyme acetylcholinesterase (AChE) lead to an increase in the availability of the neurotransmitter acetylcholine in the synaptic cleft and the antioxidant and anti-inflammatory effects, as phenomena associated with neurodegeneration mechanisms.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
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Cianobactérias
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Fármacos Neuroprotetores
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Doença de Alzheimer
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Anti-Inflamatórios
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Antioxidantes
Limite:
Animals
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Humans
Idioma:
En
Revista:
Mar Drugs
Ano de publicação:
2021
Tipo de documento:
Article