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Neutral Re(I) Complex Platform for Live Intracellular Imaging.
Gillam, Todd A; Caporale, Chiara; Brooks, Robert D; Bader, Christie A; Sorvina, Alexandra; Werrett, Melissa V; Wright, Phillip J; Morrison, Janna L; Massi, Massimiliano; Brooks, Doug A; Zacchini, Stefano; Hickey, Shane M; Stagni, Stefano; Plush, Sally E.
Afiliação
  • Gillam TA; UniSA Clinical and Health Sciences, University of South Australia, North Tce, Adelaide, South Australia 5000, Australia.
  • Caporale C; UniSA STEM, Future Industries Institute, University of South Australia, Mawson Lakes, South Australia 5095, Australia.
  • Brooks RD; Department of Chemistry, Curtin University, Kent St., Bentley, Western Australia 6102, Australia.
  • Bader CA; UniSA Clinical and Health Sciences, University of South Australia, North Tce, Adelaide, South Australia 5000, Australia.
  • Sorvina A; UniSA Clinical and Health Sciences, University of South Australia, North Tce, Adelaide, South Australia 5000, Australia.
  • Werrett MV; UniSA Clinical and Health Sciences, University of South Australia, North Tce, Adelaide, South Australia 5000, Australia.
  • Wright PJ; School of Chemistry, Monash University, Clayton, Melbourne, Victoria 3800, Australia.
  • Morrison JL; Department of Chemistry, Curtin University, Kent St., Bentley, Western Australia 6102, Australia.
  • Massi M; UniSA Clinical and Health Sciences, University of South Australia, North Tce, Adelaide, South Australia 5000, Australia.
  • Brooks DA; Department of Chemistry, Curtin University, Kent St., Bentley, Western Australia 6102, Australia.
  • Zacchini S; UniSA Clinical and Health Sciences, University of South Australia, North Tce, Adelaide, South Australia 5000, Australia.
  • Hickey SM; Department of Industrial Chemistry "Toso Montanari", University of Bologna, Viale Risorgimento 4, Bologna 40136, Italy.
  • Stagni S; UniSA Clinical and Health Sciences, University of South Australia, North Tce, Adelaide, South Australia 5000, Australia.
  • Plush SE; Department of Industrial Chemistry "Toso Montanari", University of Bologna, Viale Risorgimento 4, Bologna 40136, Italy.
Inorg Chem ; 60(14): 10173-10185, 2021 Jul 19.
Article em En | MEDLINE | ID: mdl-34210122
ABSTRACT
Luminescent metal complexes are a valuable platform for the generation of cell imaging agents. However, many metal complexes are cationic, a factor that can dominate the intracellular accumulation to specific organelles. Neutral Re(I) complexes offer a more attractive platform for the development of bioconjugated imaging agents, where charge cannot influence their intracellular distribution. Herein, we report the synthesis of a neutral complex (ReAlkyne), which was used as a platform for the generation of four carbohydrate-conjugated imaging agents via Cu(I)-catalyzed azide-alkyne cycloaddition. A comprehensive evaluation of the physical and optical properties of each complex is provided, together with a determination of their utility as live cell imaging agents in H9c2 cardiomyoblasts. Unlike their cationic counterparts, many of which localize within mitochondria, these neutral complexes have localized within the endosomal/lysosomal network, a result consistent with examples of dinuclear carbohydrate-appended neutral Re(I) complexes that have been reported. This further demonstrates the utility of these neutral Re(I) complex imaging platforms as viable imaging platforms for the development of bioconjugated cell imaging agents.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rênio / Espaço Intracelular / Complexos de Coordenação / Imagem Molecular Idioma: En Revista: Inorg Chem Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rênio / Espaço Intracelular / Complexos de Coordenação / Imagem Molecular Idioma: En Revista: Inorg Chem Ano de publicação: 2021 Tipo de documento: Article