Boronic Acid Pairs for Sequential Bioconjugation.
Org Lett
; 23(14): 5334-5338, 2021 07 16.
Article
em En
| MEDLINE
| ID: mdl-34212723
ABSTRACT
Boronic acids can play diverse roles when applied in biological environments, and employing boronic acid structures in tandem could provide new tools for multifunctional probes. This Letter describes a pair of boronic acid functional groups, 2-nitro-arylboronic acid (NAB) and (E)-alkenylboronic acid (EAB), that enable sequential cross-coupling through stepwise nickel- and copper-catalyzed processes. The selective coupling of NAB groups enables the preparation of stapled peptides, protein-protein conjugates, and other bioconjugates.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácidos Borônicos
/
Nitrocompostos
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2021
Tipo de documento:
Article