The Phenomenon of Multidrug Resistance in Glioblastomas.

Chernov, Alexandr N; Alaverdian, Diana A; Galimova, Elvira S; Renieri, Alessandra; Frullanti, Elisa; Meloni, Ilaria; Shamova, Olga V

Chernov, Alexandr N; Alaverdian, Diana A; Galimova, Elvira S; Renieri, Alessandra; Frullanti, Elisa; Meloni, Ilaria; Shamova, Olga V.

Afiliação

Chernov AN; Institute of Experimental Medicine, Russian Academy of Medical Sciences, Saint-Petersburg, Russia.
Alaverdian DA; MedicalGenetics, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Galimova ES; MedBiotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Renieri A; I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint-Petersburg, Russia.
Frullanti E; MedicalGenetics, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Meloni I; MedBiotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Shamova OV; Genetica Medica, Azienda Ospedaliero-Universitaria Senese, Siena, Italy.

Hematol Oncol Stem Cell Ther ; 15(2): 1-7, 2022 Jun 01.

Article em En | MEDLINE | ID: mdl-34216549

ABSTRACT

ABSTRACT

The most common and aggressive brain tumor in the adult population is glioblastoma (GBM). The lifespan of patients does not exceed 22 months. One of the reasons for the low effectiveness of GBM treatment is its radioresistance and chemoresistance. In the current review, we discuss the phenomenon of multidrug resistance of GBM in the context of the expression of ABC family transporter proteins and the mechanisms of proliferation, angiogenesis, and recurrence. We focused on the search of molecular targets among growth factors, receptors, signal transduction proteins, microRNAs, transcription factors, proto-oncogenes, tumor suppressor genes, and their single-nucleotide polymorphisms.

Assuntos

Neoplasias Encefálicas; Resistência a Múltiplos Medicamentos; Resistencia a Medicamentos Antineoplásicos; Glioblastoma; MicroRNAs; Humanos; Neoplasias Encefálicas/tratamento farmacológico; Neoplasias Encefálicas/genética; Neoplasias Encefálicas/metabolismo; Linhagem Celular Tumoral; Proliferação de Células; Resistência a Múltiplos Medicamentos/genética; Glioblastoma/tratamento farmacológico; Glioblastoma/genética; Glioblastoma/metabolismo; MicroRNAs/genética; MicroRNAs/metabolismo; MicroRNAs/uso terapêutico; Transdução de Sinais; Resistencia a Medicamentos Antineoplásicos/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioblastoma / Resistência a Múltiplos Medicamentos / Resistencia a Medicamentos Antineoplásicos / MicroRNAs Limite: Humans Idioma: En Revista: Hematol Oncol Stem Cell Ther Ano de publicação: 2022 Tipo de documento: Article

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