Natural soluble epoxide hydrolase inhibitors from Inula britanica and their potential interactions with soluble epoxide hydrolase: Insight from inhibition kinetics and molecular dynamics.

Zhao, Wen-Yu; Yan, Juan-Juan; Zhang, Min; Wang, Chao; Feng, Lei; Lv, Xia; Huo, Xiao-Kui; Sun, Cheng-Peng; Chen, Li-Xia; Ma, Xiao-Chi

Zhao, Wen-Yu; Yan, Juan-Juan; Zhang, Min; Wang, Chao; Feng, Lei; Lv, Xia; Huo, Xiao-Kui; Sun, Cheng-Peng; Chen, Li-Xia; Ma, Xiao-Chi.

Afiliação

Zhao WY; Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College of Pharmacy, College (Institute) of Integrative Medicine, Dalian Medical University, Dalian, China.
Yan JJ; Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
Zhang M; Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College of Pharmacy, College (Institute) of Integrative Medicine, Dalian Medical University, Dalian, China.
Wang C; Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College of Pharmacy, College (Institute) of Integrative Medicine, Dalian Medical University, Dalian, China.
Feng L; Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College of Pharmacy, College (Institute) of Integrative Medicine, Dalian Medical University, Dalian, China.
Lv X; Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College of Pharmacy, College (Institute) of Integrative Medicine, Dalian Medical University, Dalian, China.
Huo XK; Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College of Pharmacy, College (Institute) of Integrative Medicine, Dalian Medical University, Dalian, China.
Sun CP; Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College of Pharmacy, College (Institute) of Integrative Medicine, Dalian Medical University, Dalian, China. Electronic address: suncp146@163.com.
Chen LX; Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China. Electronic address: syzyclx@163.com.
Ma XC; Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College of Pharmacy, College (Institute) of Integrative Medicine, Dalian Medical University, Dalian, China; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical Univ

Chem Biol Interact ; 345: 109571, 2021 Aug 25.

Article em En | MEDLINE | ID: mdl-34217688

Assuntos

Produtos Biológicos/metabolismo; Produtos Biológicos/farmacologia; Epóxido Hidrolases/antagonistas & inibidores; Epóxido Hidrolases/metabolismo; Inula/química; Simulação de Dinâmica Molecular; Inibidores Enzimáticos/metabolismo; Inibidores Enzimáticos/farmacologia; Epóxido Hidrolases/química; Cinética; Simulação de Acoplamento Molecular; Ligação Proteica; Conformação Proteica; Solubilidade

Palavras-chave

Molecular dynamics; Potential interaction; Soluble epoxide hydrolase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Inula / Epóxido Hidrolases / Simulação de Dinâmica Molecular Idioma: En Revista: Chem Biol Interact Ano de publicação: 2021 Tipo de documento: Article

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