Upregulation of COX-2 and PGE<sub>2</sub> Induced by TNF-&#945; Mediated Through TNFR1/MitoROS/PKC&#945;/P38 MAPK, JNK1/2/FoxO1 Cascade in Human Cardiac Fibroblasts.

Yang, Chuen-Mao; Yang, Chien-Chung; Hsiao, Li-Der; Yu, Chia-Ying; Tseng, Hui-Ching; Hsu, Chih-Kai; Situmorang, Jiro Hasegawa

Upregulation of COX-2 and PGE₂ Induced by TNF-α Mediated Through TNFR1/MitoROS/PKCα/P38 MAPK, JNK1/2/FoxO1 Cascade in Human Cardiac Fibroblasts.

Yang, Chuen-Mao; Yang, Chien-Chung; Hsiao, Li-Der; Yu, Chia-Ying; Tseng, Hui-Ching; Hsu, Chih-Kai; Situmorang, Jiro Hasegawa.

Afiliação

Yang CM; Department of Pharmacology, College of Medicine, China Medical University, Taichung, 40402, Taiwan.
Yang CC; Ph.D. Program for Biotech Pharmaceutical Industry, China Medical University, Taichung, 40402, Taiwan.
Hsiao LD; Department of Post-Baccalaureate Veterinary Medicine, College of Medical and Health Science, Asia University, Wufeng, Taichung, 41354, Taiwan.
Yu CY; Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital at Tao-Yuan, Kwei-San, Tao-Yuan, 33302, Taiwan.
Tseng HC; School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan, 33302, Taiwan.
Hsu CK; Department of Pharmacology, College of Medicine, China Medical University, Taichung, 40402, Taiwan.
Situmorang JH; Department of Pharmacology, College of Medicine, China Medical University, Taichung, 40402, Taiwan.

J Inflamm Res ; 14: 2807-2824, 2021.

Article em En | MEDLINE | ID: mdl-34234507

Palavras-chave

COX-2; FoxO1; PGE2; PKC-α; TNF-α; mitochondrial ROS

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Inflamm Res Ano de publicação: 2021 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Inflamm Res Ano de publicação: 2021 Tipo de documento: Article