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Pillar[5]arene-based supramolecular photosensitizer for enhanced hypoxic-tumor therapeutic effectiveness.
Chao, Shuang; Shen, Ziyan; Pei, Yuxin; Lv, Yinghua; Chen, Xiaolin; Ren, Jiaming; Yang, Ke; Pei, Zhichao.
Afiliação
  • Chao S; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, P. R. China. peizc@nwafu.edu.cn.
  • Shen Z; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, P. R. China. peizc@nwafu.edu.cn.
  • Pei Y; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, P. R. China. peizc@nwafu.edu.cn.
  • Lv Y; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, P. R. China. peizc@nwafu.edu.cn.
  • Chen X; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, P. R. China. peizc@nwafu.edu.cn.
  • Ren J; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, P. R. China. peizc@nwafu.edu.cn.
  • Yang K; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, P. R. China. peizc@nwafu.edu.cn.
  • Pei Z; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, P. R. China. peizc@nwafu.edu.cn.
Chem Commun (Camb) ; 57(62): 7625-7628, 2021 Aug 03.
Article em En | MEDLINE | ID: mdl-34235523
A galactose-targeting supramolecular photosensitizer system DOX@GP5⊃NBSPD was constructed based on a host-guest inclusion complex. The supramolecular system could achieve efficient delivery of DOX/NBS and selective release under GSH stimulation. In vitro studies revealed that this supramolecular DOX/NBS co-delivery system exhibited high ROS production and excellent cancer cell damage capability in a hypoxic environment. This strategy can therefore achieve enhanced hypoxic-tumor therapeutic effectiveness by chemo-photodynamic combination.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fármacos Fotossensibilizantes / Calixarenos / Hipóxia Tumoral Limite: Humans Idioma: En Revista: Chem Commun (Camb) Ano de publicação: 2021 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fármacos Fotossensibilizantes / Calixarenos / Hipóxia Tumoral Limite: Humans Idioma: En Revista: Chem Commun (Camb) Ano de publicação: 2021 Tipo de documento: Article