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Evaluation of the early-phase [18F]AV45 PET as an optimal surrogate of [18F]FDG PET in ageing and Alzheimer's clinical syndrome.
Vanhoutte, Matthieu; Landeau, Brigitte; Sherif, Siya; de la Sayette, Vincent; Dautricourt, Sophie; Abbas, Ahmed; Manrique, Alain; Chocat, Anne; Chételat, Gaël.
Afiliação
  • Vanhoutte M; Inserm UMR-S U1237, Caen-Normandie University, GIP Cyceron, Caen, France. Electronic address: mvanhoutte@cyceron.fr.
  • Landeau B; Inserm UMR-S U1237, Caen-Normandie University, GIP Cyceron, Caen, France.
  • Sherif S; Inserm UMR-S U1237, Caen-Normandie University, GIP Cyceron, Caen, France.
  • de la Sayette V; Inserm U1077, Caen-Normandie University, École Pratique des Hautes Études, Caen, France; University Hospital, Neurology Department, Caen, France.
  • Dautricourt S; Inserm UMR-S U1237, Caen-Normandie University, GIP Cyceron, Caen, France; University Hospital, Neurology Department, Caen, France.
  • Abbas A; Inserm U1077, Caen-Normandie University, École Pratique des Hautes Études, Caen, France.
  • Manrique A; University Hospital, Nuclear Medicine Department, Caen, France.
  • Chocat A; Inserm UMR-S U1237, Caen-Normandie University, GIP Cyceron, Caen, France.
  • Chételat G; Inserm UMR-S U1237, Caen-Normandie University, GIP Cyceron, Caen, France; Inserm U1077, Caen-Normandie University, École Pratique des Hautes Études, Caen, France. Electronic address: chetelat@cyceron.fr.
Neuroimage Clin ; 31: 102750, 2021.
Article em En | MEDLINE | ID: mdl-34247116
Dual-phase [18F]AV45 positron emission tomography (PET) is highly promising in the assessment of neurodegenerative diseases, allowing to obtain information on both neurodegeneration (early-phase; eAV45) and amyloid deposition (late-phase; lAV45) which are highly complementary; yet eAV45 needs further evaluation. This study aims at validating eAV45 as an optimal proxy of [18F]FDG PET in a large mixed-population of healthy ageing and Alzheimer's clinical syndrome participants (n = 191) who had [18F]FDG PET, eAV45 and lAV45 scans. We found early time frame 0-4 min to give maximal correlation with [18F]FDG PET and minimal correlation with lAV45. Moreover, maximal overlap of [18F]FDG PET versus eAV45 associations with clinical diagnosis and cognition was obtained with pons scaling. Across reference regions, classification performance between clinical subgroups was similar for both eAV45 and [18F]FDG PET. These findings highlight the optimal use of eAV45 to assess neurodegeneration as a validated proxy of [18F]FDG PET. On top of this purpose, this study showed that combined [18F]AV45 PET dual-biomarker even outperformed [18F]FDG PET or lAV45 alone.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fluordesoxiglucose F18 / Doença de Alzheimer Limite: Humans Idioma: En Revista: Neuroimage Clin Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fluordesoxiglucose F18 / Doença de Alzheimer Limite: Humans Idioma: En Revista: Neuroimage Clin Ano de publicação: 2021 Tipo de documento: Article