Sex differences in dementia and response to a lifestyle intervention: Evidence from Nordic population-based studies and a prevention trial.
Alzheimers Dement
; 17(7): 1166-1178, 2021 07.
Article
em En
| MEDLINE
| ID: mdl-34255432
ABSTRACT
INTRODUCTION:
Evidence on sex differences in the risk for dementia has been mixed. The goal was to assess sex differences in the development of dementia, and in the effects of a lifestyle intervention.METHODS:
Two strategies were adopted, one using combined data from three large Nordic population-based cohort studies (n = 2289), adopting dementia as outcome, and 2-year multidomain lifestyle intervention (n = 1260), adopting cognitive change as outcome.RESULTS:
There was higher risk for dementia after age 80 years in women. The positive effects of the lifestyle intervention on cognition did not significantly differ between men and women. Sex-specific analyses suggested that different vascular, lifestyle, and psychosocial risk factors are important for women and men in mid- and late-life.CONCLUSION:
Women had higher risk for dementia among the oldest individuals. Lifestyle interventions may be effectively implemented among older men and women.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
Base de dados:
MEDLINE
Assunto principal:
Demência
/
Estilo de Vida
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
Alzheimers Dement
Ano de publicação:
2021
Tipo de documento:
Article