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Association of serum monomeric periostin level with outcomes of acute exacerbation of idiopathic pulmonary fibrosis and fibrosing nonspecific interstitial pneumonia.
Shimizu, Hiroshige; Sakamoto, Susumu; Okamoto, Masaki; Isshiki, Takuma; Ono, Junya; Shimizu, Shigeki; Hoshino, Tomoaki; Izuhara, Kenji; Homma, Sakae.
Afiliação
  • Shimizu H; Department of Respiratory Medicine, Toho University Omori Medical Center, Tokyo, Japan.
  • Sakamoto S; Department of Respiratory Medicine, Toho University Omori Medical Center, Tokyo, Japan.
  • Okamoto M; Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Fukuoka, Japan.
  • Isshiki T; Department of Respiratory Medicine, Toho University Omori Medical Center, Tokyo, Japan.
  • Ono J; Shino-Test Corporation, Sagamihara, Japan.
  • Shimizu S; Department of Pathology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan.
  • Hoshino T; Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Fukuoka, Japan.
  • Izuhara K; Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan.
  • Homma S; Department of Respiratory Medicine, Toho University Omori Medical Center, Tokyo, Japan.
Ann Transl Med ; 9(9): 739, 2021 May.
Article em En | MEDLINE | ID: mdl-34268352
BACKGROUND: The associations of serum monomeric periostin (M-PN) level and serial change in M-PN with acute exacerbation of chronic fibrosing interstitial pneumonia (AE-FIP) are unclear. METHODS: We prospectively measured serum M-PN level from onset of AE to day 14 in 37 patients with AE-FIP and evaluated its association with outcome. To determine localization of periostin expression, immunohistochemical staining of pathological lung tissue from autopsy cases of AE-IPF was evaluated. RESULTS: Data from 37 AE-FIP patients (28 men; age 73.9±7.8 years) were analyzed. With healthy controls as reference, serum M-PN level was significantly higher in patients with AE-FIP (P=0.02) but not in those with stable idiopathic pulmonary fibrosis (P=1.00). M-PN was significantly lower on day 7 than at AE-FIP onset in survivors [14.6±5.8 vs. 9.3±2.8 ng/mL (onset to day 7: P<0.001)] but not in non-survivors [14.6±5.1 vs. 13.2±5.1 ng/mL (onset to day 7: P=0.07)]. In analysis using a cut-off value for serial change in M-PN (ΔM-PN), 3-month survival was 92.3% in the ΔM-PN decrease group and 36% in the ΔM-PN increase group (P=0.002). In multivariate analysis, 3-month survival tended to be associated with high ΔM-PN (OR: 12.4, 95% CI: 0.82-187.9, P=0.069). CONCLUSIONS: Serial change in serum M-PN level may be a prognostic indicator of AE-FIP.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 4_TD Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Revista: Ann Transl Med Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 4_TD Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Revista: Ann Transl Med Ano de publicação: 2021 Tipo de documento: Article