Optimized Reversed-Phase Liquid Chromatography/Mass Spectrometry Methods for Intact Protein Analysis and Peptide Mapping of Adeno-Associated Virus Proteins.

Zhang, Ximo; Jin, Xiaoying; Liu, Lin; Zhang, Zichuan; Koza, Stephan; Yu, Ying Qing; Chen, Weibin

Zhang, Ximo; Jin, Xiaoying; Liu, Lin; Zhang, Zichuan; Koza, Stephan; Yu, Ying Qing; Chen, Weibin.

Afiliação

Zhang X; Scientific Operations, Waters Corporation, Milford, Massachusetts, USA.
Jin X; Global CMC Development, Sanofi, Framingham, Massachusetts, USA.
Liu L; Global CMC Development, Sanofi, Framingham, Massachusetts, USA.
Zhang Z; Global CMC Development, Sanofi, Framingham, Massachusetts, USA.
Koza S; Scientific Operations, Waters Corporation, Milford, Massachusetts, USA.
Yu YQ; Scientific Operations, Waters Corporation, Milford, Massachusetts, USA.
Chen W; Scientific Operations, Waters Corporation, Milford, Massachusetts, USA.

Hum Gene Ther ; 32(23-24): 1501-1511, 2021 12.

Article em En | MEDLINE | ID: mdl-34278837

Assuntos

Cromatografia de Fase Reversa; Dependovirus; Capsídeo; Dependovirus/genética; Vetores Genéticos/genética; Espectrometria de Massas; Mapeamento de Peptídeos

Palavras-chave

AAV; AAV analytical development; AAV attribute monitoring; AAV peptide mapping; AAV protein analysis; vector characterization

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dependovirus / Cromatografia de Fase Reversa Tipo de estudo: Guideline / Risk_factors_studies Idioma: En Revista: Hum Gene Ther Ano de publicação: 2021 Tipo de documento: Article

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