Viridans Group Streptococci in Pediatric Leukemia and Stem Cell Transplant: Review of a Risk-stratified Guideline for Empiric Vancomycin in Febrile Neutropenia.

Ruhayel, Sandra D; Foley, David A; Hamilton, Kate; Ferguson, Patricia; Kotecha, Rishi S; Bowen, Asha C; Yeoh, Daniel K

Ruhayel, Sandra D; Foley, David A; Hamilton, Kate; Ferguson, Patricia; Kotecha, Rishi S; Bowen, Asha C; Yeoh, Daniel K.

Afiliação

Ruhayel SD; From the Department of Paediatric and Adolescent Haematology, Oncology, Blood and Marrow Transplantation, Perth Children's Hospital.
Foley DA; Infectious Diseases Department, Perth Children's Hospital, Perth, Western Australia.
Hamilton K; Centre for Infectious Diseases and Microbiology, Westmead Hospital, Sydney, New South Wales.
Ferguson P; Centre for Infectious Diseases and Microbiology, Westmead Hospital, Sydney, New South Wales.
Kotecha RS; From the Department of Paediatric and Adolescent Haematology, Oncology, Blood and Marrow Transplantation, Perth Children's Hospital.
Bowen AC; Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia.
Yeoh DK; School of Pharmacy and Biomedical Sciences, Curtin University.

Pediatr Infect Dis J ; 40(9): 832-834, 2021 09 01.

Article em En | MEDLINE | ID: mdl-34285167

ABSTRACT

ABSTRACT

Viridans group streptococci (VGS) are an important cause of sepsis in immunosuppressed children. We reviewed the effectiveness of risk-stratified addition of vancomycin to empiric febrile neutropenia therapy among 107 children with leukemia or undergoing an allogeneic transplant. Of 19 VGS bacteremia episodes, 78.9% were susceptible to risk-stratified antibiotics including 100% from high-risk patients. All blood cultures were flagged positive within 24 hours.

Assuntos

Antibacterianos/uso terapêutico; Neutropenia Febril/tratamento farmacológico; Neutropenia Febril/microbiologia; Transplante de Células-Tronco Hematopoéticas/efeitos adversos; Leucemia/complicações; Infecções Estreptocócicas/tratamento farmacológico; Vancomicina/uso terapêutico; Estreptococos Viridans/efeitos dos fármacos; Antibacterianos/farmacologia; Criança; Pré-Escolar; Feminino; Humanos; Leucemia/microbiologia; Masculino; Testes de Sensibilidade Microbiana; Guias de Prática Clínica como Assunto; Estudos Prospectivos

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Estreptocócicas / Vancomicina / Leucemia / Transplante de Células-Tronco Hematopoéticas / Estreptococos Viridans / Neutropenia Febril / Antibacterianos Tipo de estudo: Etiology_studies / Guideline / Observational_studies / Risk_factors_studies Limite: Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Pediatr Infect Dis J Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google