Are serum cortisol measurements by immunoassays reliable?: A case series.
Med Res Arch
; 8(5)2020 May.
Article
em En
| MEDLINE
| ID: mdl-34291157
ABSTRACT
Routinely used automated immunoassays have been found to give unrealiable measurements of thyroid hormones in the presence of either high or low levels of thyroxine-binding globulin. Thyroid hormones are not the only analytes bound to specific binding proteins that are measured by immunoassays. Preliminary data from a series of cases, comparing IA measurements to those obtained by liquid chromatography-tandem mass spectrometry, reveal for the first time that IA measurements report falsely low (by an average of 27%) serum cortisol concentrations. Initial findings suggest that IA measurements of serum cortisol are affected by high concentrations of corticosteroid binding globulin.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Med Res Arch
Ano de publicação:
2020
Tipo de documento:
Article