Structure of the molecular bushing of the bacterial flagellar motor.
Nat Commun
; 12(1): 4469, 2021 07 22.
Article
em En
| MEDLINE
| ID: mdl-34294704
ABSTRACT
The basal body of the bacterial flagellum is a rotary motor that consists of several rings (C, MS and LP) and a rod. The LP ring acts as a bushing supporting the distal rod for its rapid and stable rotation without much friction. Here, we use electron cryomicroscopy to describe the LP ring structure around the rod, at 3.5 Å resolution, from Salmonella Typhimurium. The structure shows 26-fold rotational symmetry and intricate intersubunit interactions of each subunit with up to six partners, which explains the structural stability. The inner surface is charged both positively and negatively. Positive charges on the P ring (the part of the LP ring that is embedded within the peptidoglycan layer) presumably play important roles in its initial assembly around the rod with a negatively charged surface.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
/
Proteínas Motores Moleculares
/
Flagelos
Idioma:
En
Revista:
Nat Commun
Ano de publicação:
2021
Tipo de documento:
Article