Design and Synthesis of New Acridone-Based Nitric Oxide Fluorescent Probe.
Molecules
; 26(14)2021 Jul 17.
Article
em En
| MEDLINE
| ID: mdl-34299615
ABSTRACT
Nitric oxide (NO) is an important signaling molecule involved in a wide range of physiological and pathological processes. Fluorescent imaging is a useful tool for monitoring NO concentration, which could be essential in various biological and biochemical studies. Here, we report the design of a novel small-molecule fluorescent probe based on 9(10H)acridone moiety for nitric oxide sensing. 7,8-Diamino-4-carboxy-10-methyl-9(10H)acridone reacts with NO in aqueous media in the presence of O2, yielding a corresponding triazole derivative with fivefold increased fluorescence intensity. The probe was shown to be capable of nitric oxide sensing in living Jurkat cells.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Acridonas
/
Corantes Fluorescentes
/
Óxido Nítrico
Limite:
Humans
Idioma:
En
Revista:
Molecules
Ano de publicação:
2021
Tipo de documento:
Article