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Oxidative stress parameters as biomarkers of bladder cancer development and progression.
Wigner, Paulina; Szymanska, Beata; Bijak, Michal; Sawicka, Ewa; Kowal, Pawel; Marchewka, Zofia; Saluk-Bijak, Joanna.
Afiliação
  • Wigner P; Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236, Lodz, Poland. paulina.wigner@biol.uni.lodz.pl.
  • Szymanska B; Department of Toxicology, Faculty of Pharmacy and Division of Laboratory, Wroclaw Medical University, Borowska 211, 50-556, Wroclaw, Poland.
  • Bijak M; Biohazard Prevention Centre, Faculty of Biology and Environmental Protection, University of Lodz, 90-136, Lodz, Poland.
  • Sawicka E; Department of Toxicology, Faculty of Pharmacy and Division of Laboratory, Wroclaw Medical University, Borowska 211, 50-556, Wroclaw, Poland.
  • Kowal P; Department and Clinic of Urology and Urological Oncology, Faculty of Postgraduate Medical Training, Wroclaw Medical University, Kamienskiego 73a, 51-124, Wroclaw, Poland.
  • Marchewka Z; Department of Toxicology, Faculty of Pharmacy and Division of Laboratory, Wroclaw Medical University, Borowska 211, 50-556, Wroclaw, Poland.
  • Saluk-Bijak J; Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236, Lodz, Poland.
Sci Rep ; 11(1): 15134, 2021 07 23.
Article em En | MEDLINE | ID: mdl-34302052
The epidemiological studies confirm that the overproduction of free radical is an important factor of cancer induction as well as development, and loss of antioxidant systems efficiency is associated with an increased risk of carcinogenesis. While bladder cancer is the fourth most common type of cancer all over the world, there is little evidence of the advancing changes in oxidative/nitrative stress during the progression of bladder cancer. Our study aimed to investigate the plasma levels of typical markers of oxidative/nitrative stress depending on the clinical classification of bladder cancer differentiation and infiltration degree. We examined 40 patients with newly diagnosed bladder cancer and 20 healthy volunteers as a control group. We analysed the plasma levels of protein carbonyls, thiol groups, 3-nitrotyrosine, lipid peroxidation, as well as non-enzymatic plasma antioxidant capacity using DPPH· and ABTS·+ radicals. We confirmed that all analysed biomarkers are higher in enrolled BC patients than in healthy subjects. Furthermore, our findings demonstrate a positive correlation between the degree of bladder cancer progression and the level of oxidative stress, but no correlation in the case of NT-3. Based on obtained results, we might conclude that during carcinogenesis of the bladder increased oxidative damage of biomolecules is manifested. This indicates the participation of oxidative stress in the development of bladder cancer, and it is important the ensure the proper antioxidant protection.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Bexiga Urinária / Biomarcadores / Estresse Oxidativo Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Bexiga Urinária / Biomarcadores / Estresse Oxidativo Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Article