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Baricitinib prevents GvHD by increasing Tregs via JAK3 and treats established GvHD by promoting intestinal tissue repair via EGFR.
Kim, Sena; Ashami, Kidist; Lim, Sora; Staser, Karl; Vij, Kiran; Santhanam, Srikanth; Ritchey, Julie; Peterson, Sarah; Gao, Feng; Ciorba, Matthew A; Cooper, Matthew L; DiPersio, John F; Choi, Jaebok.
Afiliação
  • Kim S; Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
  • Ashami K; Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
  • Lim S; Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
  • Staser K; Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
  • Vij K; Division of Dermatology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
  • Santhanam S; Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
  • Ritchey J; Inflammatory Bowel Diseases Center and Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
  • Peterson S; Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
  • Gao F; Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
  • Ciorba MA; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA.
  • Cooper ML; Inflammatory Bowel Diseases Center and Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
  • DiPersio JF; Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
  • Choi J; Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Leukemia ; 36(1): 292-295, 2022 01.
Article em En | MEDLINE | ID: mdl-34304247
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Purinas / Pirazóis / Sulfonamidas / Azetidinas / Linfócitos T Reguladores / Janus Quinase 3 / Receptores ErbB / Doença Enxerto-Hospedeiro / Intestinos Limite: Animals Idioma: En Revista: Leukemia Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Purinas / Pirazóis / Sulfonamidas / Azetidinas / Linfócitos T Reguladores / Janus Quinase 3 / Receptores ErbB / Doença Enxerto-Hospedeiro / Intestinos Limite: Animals Idioma: En Revista: Leukemia Ano de publicação: 2022 Tipo de documento: Article