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Discovery of novel pyrazolopyrimidine derivatives as potent mTOR/HDAC bi-functional inhibitors via pharmacophore-merging strategy.
Zhang, Mingming; Wei, Wei; Peng, Chengjun; Ma, Xiaodong; He, Xiao; Zhang, Heng; Zhou, Mingkang.
Afiliação
  • Zhang M; College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China.
  • Wei W; Department of Clinical Laboratory, The First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, China.
  • Peng C; College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China. Electronic address: Peng8915@ahtcm.edu.cn.
  • Ma X; College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China; Department of Medicinal Chemistry, Anhui Academy of Chinese Medicine, Hefei 230012, China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei 230012, China. Electronic address: tgmxd19
  • He X; College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China.
  • Zhang H; College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China.
  • Zhou M; College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China.
Bioorg Med Chem Lett ; 49: 128286, 2021 10 01.
Article em En | MEDLINE | ID: mdl-34314844
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Pirimidinas / Inibidores de Histona Desacetilases / Serina-Treonina Quinases TOR / Inibidores de MTOR Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Pirimidinas / Inibidores de Histona Desacetilases / Serina-Treonina Quinases TOR / Inibidores de MTOR Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2021 Tipo de documento: Article