Monoclonal antibody charge variant characterization by fully automated four-dimensional liquid chromatography-mass spectrometry.

Verscheure, Liesa; Cerdobbel, An; Sandra, Pat; Lynen, Frederic; Sandra, Koen

Verscheure, Liesa; Cerdobbel, An; Sandra, Pat; Lynen, Frederic; Sandra, Koen.

Afiliação

Verscheure L; RIC group, President Kennedypark 26, Kortrijk 8500, Belgium; Separation Science Group, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281-S4, Ghent B-9000, Belgium.
Cerdobbel A; RIC group, President Kennedypark 26, Kortrijk 8500, Belgium.
Sandra P; RIC group, President Kennedypark 26, Kortrijk 8500, Belgium; Separation Science Group, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281-S4, Ghent B-9000, Belgium.
Lynen F; Separation Science Group, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281-S4, Ghent B-9000, Belgium.
Sandra K; RIC group, President Kennedypark 26, Kortrijk 8500, Belgium; Separation Science Group, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281-S4, Ghent B-9000, Belgium. Electronic address: koen.sandra@RIC-group.com.

J Chromatogr A ; 1653: 462409, 2021 Sep 13.

Article em En | MEDLINE | ID: mdl-34325295

Assuntos

Anticorpos Monoclonais; Cromatografia Líquida; Espectrometria de Massas; Anticorpos Monoclonais/análise; Anticorpos Monoclonais/química; Cátions; Mapeamento de Peptídeos

Palavras-chave

4D-LC-MS; Cation-exchange chromatography (CEX); Monoclonal antibodies; Online trypsin digestion; Succinimide intermediates

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espectrometria de Massas / Cromatografia Líquida / Anticorpos Monoclonais Idioma: En Revista: J Chromatogr A Ano de publicação: 2021 Tipo de documento: Article

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