The treatment of Trypanosoma (Nannomonas) simiae in pigs with diminazene aceturate in combination with a 5-substituted 2-nitroimidazole compound (Ro 15-0216).

ABSTRACT

Swine Trypanosoma (N.) simiae infections were treated with diminazene aceturate and a 5-substituted 2-nitroimidazole compound (Ro 15-0216). This combination of the two trypanocidal compounds has been successful. Ten mg/kg of diminazene aceturate and 50 mg/kg of Ro 15-0216 or 20 mg/kg of diminazene aceturate and 25 mg/kg of Ro 15-0216 were equally effective, while either drug alone was ineffective. Multiple administration of compound Ro 15-0216 (4 x 20 mg/kg; 3 x 50 mg/kg) at 2 hourly intervals did not cure the animals.