Aging increases circulating BH<sub>2</sub> without modifying BH<sub>4</sub> levels and impairs peripheral vascular function in healthy adults.

Bouly, Muriel; Bourguignon, Marie-Pierre; Roesch, Susanne; Rigouin, Pascal; Gosgnach, Willy; Bossard, Elodie; Royere, Emilie; Diguet, Nicolas; Sansilvestri-Morel, Patricia; Bonnin, Ariane; Xuereb, Laura; Berson, Pascal; Komajda, Michel; Bernhardt, Peter; Tyl, Benoit

Aging increases circulating BH₂ without modifying BH₄ levels and impairs peripheral vascular function in healthy adults.

Bouly, Muriel; Bourguignon, Marie-Pierre; Roesch, Susanne; Rigouin, Pascal; Gosgnach, Willy; Bossard, Elodie; Royere, Emilie; Diguet, Nicolas; Sansilvestri-Morel, Patricia; Bonnin, Ariane; Xuereb, Laura; Berson, Pascal; Komajda, Michel; Bernhardt, Peter; Tyl, Benoit.

Afiliação

Bouly M; Cardiovascular & Metabolic Disease Centre for Therapeutic Innovation, Institut de Recherches Internationales Servier, Suresnes, France.
Bourguignon MP; Cardiovascular & Metabolic Disease Centre for Therapeutic Innovation, Institut de Recherches Servier, Suresnes, France.
Roesch S; Centre of Excellence Clinical Operations, Institut de Recherches Internationales Servier, Suresnes, France.
Rigouin P; Biostatistics Department, Keyrus Life Science, Nantes, France.
Gosgnach W; Centre of Excellence Biotechnology, Institut de Recherches Servier, Croissy, France.
Bossard E; Charles River Laboratories, Saint-Nazaire, France.
Royere E; Cardiovascular & Metabolic Disease Centre for Therapeutic Innovation, Institut de Recherches Servier, Suresnes, France.
Diguet N; Cardiovascular & Metabolic Disease Centre for Therapeutic Innovation, Institut de Recherches Servier, Suresnes, France.
Sansilvestri-Morel P; Cardiovascular & Metabolic Disease Centre for Therapeutic Innovation, Institut de Recherches Servier, Suresnes, France.
Bonnin A; Drug Safety & Pharmacokinetics Centre of Excellence, Biologie Servier, Gidy, France.
Xuereb L; Centre of Excellence Methodology and Valorisation of Data, Institut de Recherches Internationales Servier, Suresnes, France.
Berson P; Cardiovascular & Metabolic Disease Centre for Therapeutic Innovation, Institut de Recherches Servier, Suresnes, France.
Komajda M; Department of Cardiology, Hospital Saint Joseph, France/Paris Sorbonne Université France, Paris, France.
Bernhardt P; Department of Cardiology, Heart Clinic Ulm, Germany.
Tyl B; Cardiovascular & Metabolic Disease Centre for Therapeutic Innovation, Institut de Recherches Internationales Servier, Suresnes, France.

Transl Res ; 238: 36-48, 2021 12.

Article em En | MEDLINE | ID: mdl-34332154

Assuntos

Envelhecimento/fisiologia; Biopterinas/análogos & derivados; Endotélio Vascular/fisiopatologia; Adolescente; Adulto; Idoso; Animais; Biopterinas/sangue; Plaquetas/metabolismo; Vasos Sanguíneos/fisiologia; Endotélio Vascular/fisiologia; Feminino; Humanos; Masculino; Pessoa de Meia-Idade; Ratos Endogâmicos SHR; Ratos Endogâmicos WKY; Ratos Zucker; Adulto Jovem

Palavras-chave

ANOVA=analysis of variance; BH(2)=dihydrobiopterin; BH(4)=tetrahydrobiopterin; BMI=body mass index; CBF=cutaneous blood flow; CFR=coronary flow reserve; CMR=cardiac magnetic resonance; CV=cardiovascular; ECG=electrocardiogram; FMD=flow-mediated dilation; GCP=good clinical practice; LSCI=laser speckle contrast imaging; NO=nitric oxide; NOS=nitric oxide synthase; TNF-alpha=tumor necrosis factor-alpha; hs-CRP=high sensitivity C-reactive protein, IL-6=Interleukin-6

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biopterinas / Envelhecimento / Endotélio Vascular Tipo de estudo: Observational_studies Limite: Adolescent / Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Transl Res Ano de publicação: 2021 Tipo de documento: Article

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