Astrocytic c-Jun N-terminal kinase-histone deacetylase-2 cascade contributes to glutamate transporter-1 decrease and mechanical allodynia following peripheral nerve injury in rats.

Lu, Rui; Cui, Shan-Shan; Wang, Xiao-Xia; Chen, Lei; Liu, Fei; Gao, Jing; Wang, Wei

Lu, Rui; Cui, Shan-Shan; Wang, Xiao-Xia; Chen, Lei; Liu, Fei; Gao, Jing; Wang, Wei.

Afiliação

Lu R; National Clinical Research Center for Oral Diseases, State Key Laboratory of Military Stomatology, Shaanxi Key Laboratory of Stomatology, Department of Anesthesiology, School of Stomatology, the Fourth Military Medical University, Shaanxi 710032, China.
Cui SS; National Clinical Research Center for Oral Diseases, State Key Laboratory of Military Stomatology, Shaanxi Key Laboratory of Stomatology, Department of Anesthesiology, School of Stomatology, the Fourth Military Medical University, Shaanxi 710032, China; Department of Anesthesiology, Renmin Hospital
Wang XX; National Clinical Research Center for Oral Diseases, State Key Laboratory of Military Stomatology, Shaanxi Key Laboratory of Stomatology, Department of Anesthesiology, School of Stomatology, the Fourth Military Medical University, Shaanxi 710032, China.
Chen L; Department of Pain Relief, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy (Tianjin), Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Liu F; National Clinical Research Center for Oral Diseases, State Key Laboratory of Military Stomatology, Shaanxi Key Laboratory of Stomatology, Department of Anesthesiology, School of Stomatology, the Fourth Military Medical University, Shaanxi 710032, China.
Gao J; National Clinical Research Center for Oral Diseases, State Key Laboratory of Military Stomatology, Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, the Fourth Military Medical University, Shaanxi 710032, China. Electronic address: gaojing1108@126.com.
Wang W; National Clinical Research Center for Oral Diseases, State Key Laboratory of Military Stomatology, Shaanxi Key Laboratory of Stomatology, Department of Anesthesiology, School of Stomatology, the Fourth Military Medical University, Shaanxi 710032, China. Electronic address: weiwang@fmmu.edu.cn.

Brain Res Bull ; 175: 213-223, 2021 10.

Article em En | MEDLINE | ID: mdl-34333051

Assuntos

Astrócitos/patologia; Transportador 2 de Aminoácido Excitatório/genética; Histona Desacetilase 2/genética; Hiperalgesia/patologia; Proteínas Quinases JNK Ativadas por Mitógeno/genética; Traumatismos dos Nervos Periféricos/genética; Traumatismos dos Nervos Periféricos/patologia; Transdução de Sinais/genética; Animais; Antracenos/farmacologia; Carbamatos/farmacologia; Células Cultivadas; Etanercepte/metabolismo; Proteínas Quinases JNK Ativadas por Mitógeno/antagonistas & inibidores; Masculino; Microglia/efeitos dos fármacos; Minociclina/farmacologia; Neuralgia/genética; Neuralgia/patologia; Ratos; Ratos Sprague-Dawley; Nervos Espinhais/lesões; Fator de Necrose Tumoral alfa/farmacologia

Palavras-chave

Astrocytes; C-Jun N-terminal kinase; Glutamate transporter-1; Histone deacetylase; Neuropathic pain; Spinal cord

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Astrócitos / Transportador 2 de Aminoácido Excitatório / Proteínas Quinases JNK Ativadas por Mitógeno / Histona Desacetilase 2 / Traumatismos dos Nervos Periféricos / Hiperalgesia Limite: Animals Idioma: En Revista: Brain Res Bull Ano de publicação: 2021 Tipo de documento: Article

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