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Structure and Function of Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs) and Their Role in Cardiovascular Diseases.
Luan, Yi; Luan, Ying; Yuan, Rui-Xia; Feng, Qi; Chen, Xing; Yang, Yang.
Afiliação
  • Luan Y; Department of Translational Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
  • Luan Y; Department of Physiology and Neurobiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China.
  • Yuan RX; Department of Translational Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
  • Feng Q; Research Institute of Nephrology, Zhengzhou University, Zhengzhou 450052, China.
  • Chen X; Department of Translational Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
  • Yang Y; Department of Translational Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Oxid Med Cell Longev ; 2021: 4578809, 2021.
Article em En | MEDLINE | ID: mdl-34336092
Abnormal function of suborganelles such as mitochondria and endoplasmic reticulum often leads to abnormal function of cardiomyocytes or vascular endothelial cells and cardiovascular disease (CVD). Mitochondria-associated membrane (MAM) is involved in several important cellular functions. Increasing evidence shows that MAM is involved in the pathogenesis of CVD. MAM mediates multiple cellular processes, including calcium homeostasis regulation, lipid metabolism, unfolded protein response, ROS, mitochondrial dynamics, autophagy, apoptosis, and inflammation, which are key risk factors for CVD. In this review, we discuss the structure of MAM and MAM-associated proteins, their role in CVD progression, and the potential use of MAM as the therapeutic targets for CVD treatment.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Retículo Endoplasmático / Membranas Mitocondriais Limite: Humans Idioma: En Revista: Oxid Med Cell Longev Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Retículo Endoplasmático / Membranas Mitocondriais Limite: Humans Idioma: En Revista: Oxid Med Cell Longev Ano de publicação: 2021 Tipo de documento: Article