Chemotherapy for ovarian cancer during pregnancy: A systematic review and meta-analysis of case reports and series.
J Obstet Gynaecol Res
; 47(10): 3425-3436, 2021 Oct.
Article
em En
| MEDLINE
| ID: mdl-34342108
ABSTRACT
AIM:
This study aims to investigate the safety and efficacy of chemotherapy in ovarian cancer patients in pregnancy.METHODS:
In this study, eligible studies were searched on PubMed, Embase, and Cochrane Library databases up to December 31, 2020. Data were calculated and presented by frequency and percentage, mean ± standard deviation (SD), and median (range), respectively. Kaplan-Meier survival analysis was performed to estimate overall survival (OS) and progression-free survival (PFS).RESULTS:
Finally, 34 studies including 40 ovarian cancer cases receiving chemotherapy during pregnancy were included. All 40 patients received chemotherapy during pregnancy. During the follow-up, seven of 37 (18.9%) women had a relapse and four of them (4/7, 57.1%) died of recurrence. Survival analysis failed to reach median OS and PFS within the follow-up (range 3-72 months). Better OS and PFS after chemotherapy in pregnancy were obtained in women with early-stage ovarian cancer (I) compared with those with advanced stage (III-IV). Neither OS nor FS differed between women treated with multi-drugs and those with monotherapy. Forty-one newborns were delivered from 40 pregnant women. Thirty-four (34/41, 82.9%) were completely healthy at birth and the end of follow-up (range 0.18-160 months). However, one newborn died 5 days after birth due to multiple congenital malformations, and another one developed Tourette's syndrome, aphasia, Asperger's syndrome as well as speech delay.CONCLUSIONS:
This meta-analysis first reveals the efficacy and safety of chemotherapy for ovarian cancer during pregnancy, especially for early-stage patients. Cisplatin or carboplatin is suggested to be used as monotherapy to reduce adverse effects.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
/
Recidiva Local de Neoplasia
Tipo de estudo:
Systematic_reviews
Limite:
Female
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Humans
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Newborn
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Pregnancy
Idioma:
En
Revista:
J Obstet Gynaecol Res
Ano de publicação:
2021
Tipo de documento:
Article