Lipopolysaccharide-induced maternal immune activation modulates microglial CX3CR1 protein expression and morphological phenotype in the hippocampus and dentate gyrus, resulting in cognitive inflexibility during late adolescence.

Fernández de Cossío, Lourdes; Lacabanne, Chloé; Bordeleau, Maude; Castino, Garance; Kyriakakis, Phillip; Tremblay, Marie-Ève

Fernández de Cossío, Lourdes; Lacabanne, Chloé; Bordeleau, Maude; Castino, Garance; Kyriakakis, Phillip; Tremblay, Marie-Ève.

Afiliação

Fernández de Cossío L; Department of Neurosciences, University of California, La Jolla, CA, USA; Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada. Electronic address: lourdes.fernandezdecossiogomez@mail.mcgill.ca.
Lacabanne C; Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada.
Bordeleau M; Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada; Axe Neurosciences, Centre de Recherche du CHU de Québec - Université Laval, Québec, QC, Canada.
Castino G; Department of Biology, École Normale Supérieure de Lyon, Université de Lyon, Lyon, France.
Kyriakakis P; Department of Bioengineering, Stanford University, Stanford, CA, USA.
Tremblay MÈ; Axe Neurosciences, Centre de Recherche du CHU de Québec - Université Laval, Québec, QC, Canada; Département de médecine moléculaire, Université Laval, Québec, QC, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada; Division of Medical Sciences, University of Vi

Brain Behav Immun ; 97: 440-454, 2021 10.

Article em En | MEDLINE | ID: mdl-34343619

Assuntos

Transtorno do Espectro Autista; Receptor 1 de Quimiocina CX3C/genética; Microglia; Adolescente; Receptor 1 de Quimiocina CX3C/metabolismo; Cognição; Giro Denteado/metabolismo; Feminino; Hipocampo/metabolismo; Humanos; Lipopolissacarídeos; Masculino; Microglia/metabolismo; Fenótipo; Gravidez

Palavras-chave

Barnes maze; CX3CR1; Cognitive inflexibility; Dentate gyrus; Fractalkine; Hippocampus; Lipopolysaccharide; Maternal immune activation; Microglia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microglia / Transtorno do Espectro Autista / Receptor 1 de Quimiocina CX3C Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adolescent / Female / Humans / Male / Pregnancy Idioma: En Revista: Brain Behav Immun Ano de publicação: 2021 Tipo de documento: Article

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