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ApoE and immunity in Alzheimer's disease and related tauopathies: Low-density lipoprotein receptor to the rescue.
Mendiola, Andrew S; Tognatta, Reshmi; Yan, Zhaoqi; Akassoglou, Katerina.
Afiliação
  • Mendiola AS; Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA 94158, USA; Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA.
  • Tognatta R; Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA 94158, USA; Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA.
  • Yan Z; Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA 94158, USA; Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA.
  • Akassoglou K; Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA 94158, USA; Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Neuron ; 109(15): 2363-2365, 2021 08 04.
Article em En | MEDLINE | ID: mdl-34352209
ABSTRACT
In this issue of Neuron, Shi et al. (2021) show a protective role for the low-density lipoprotein receptor (LDLR) in tau pathology. Brain overexpression of LDLR lowers apolipoprotein E (apoE), suppresses microglial activation, preserves myelin, and ameliorates neurodegeneration, pointing the way toward potential new therapies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tauopatias / Doença de Alzheimer Limite: Humans Idioma: En Revista: Neuron Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tauopatias / Doença de Alzheimer Limite: Humans Idioma: En Revista: Neuron Ano de publicação: 2021 Tipo de documento: Article