Your browser doesn't support javascript.
loading
Perfluoroalkyl substances and thyroid stimulating hormone levels in a highly exposed population in the Veneto Region.
Gallo, Elisa; Barbiellini Amidei, Claudio; Barbieri, Giulia; Fabricio, Aline S C; Gion, Massimo; Pitter, Gisella; Daprà, Francesca; Russo, Francesca; Gregori, Dario; Fletcher, Tony; Canova, Cristina.
Afiliação
  • Gallo E; Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
  • Barbiellini Amidei C; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
  • Barbieri G; Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
  • Fabricio ASC; Regional Center for Biomarkers, Department of Clinical Pathology, Azienda ULSS 3 Serenissima, Venice, Italy; Veneto Institute of Oncology IOV-IRCCS, Padova, Italy.
  • Gion M; Regional Center for Biomarkers, Department of Clinical Pathology, Azienda ULSS 3 Serenissima, Venice, Italy.
  • Pitter G; Screening and Health Impact Assessment Unit, Azienda Zero-Veneto Region, Padova, Italy.
  • Daprà F; Laboratory Department-Regional Agency for Environmental Prevention and Protection-Veneto Region, Venice, Italy.
  • Russo F; Directorate of Prevention, Food Safety and Veterinary Public Health-Veneto Region, Venice, Italy.
  • Gregori D; Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
  • Fletcher T; London School of Hygiene and Tropical Medicine, London, United Kingdom.
  • Canova C; Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy. Electronic address: cristina.canova@unipd.it.
Environ Res ; 203: 111794, 2022 01.
Article em En | MEDLINE | ID: mdl-34358507
BACKGROUND: Per- and poly-fluoroalkyl substances (PFAS) are persistent and widespread environmental pollutants. People living in Veneto Region (Italy) have been exposed from the late 1970s to 2013 to elevated concentrations of PFAS through drinking water. The effect of PFAS on thyroid function is still controversial and studies focusing on thyroid stimulating hormone (TSH) have shown inconsistent results. The aim of this study was to evaluate the association between serum PFAS and TSH levels and its dose-response relationship in a large population of highly exposed individuals. METHODS: A cross-sectional study was conducted on 21,424 individuals aged 14-39 living in the contaminated area. In the main analysis, participants with prevalent thyroid disease and pregnant women were excluded. Serum levels of perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), perfluorohexanesulfonic acid (PFHxS) and perfluorononanoic acid (PFNA) were measured. Generalized Additive Models were used to evaluate the association between TSH levels and serum PFAS, using thin plate spline smooth terms to model the potential non-linear relationship. Models were stratified by sex and age group and adjusted for potential confounders. A secondary analysis was conducted to evaluate the association between PFAS with prevalent self-reported thyroid disorders. RESULTS: We found no association between TSH and any type of PFAS among adolescents or women. A decrease in TSH concentration was observed in association with an IQR increase in PFHxS and a mild decrease in TSH at low levels of PFOA, PFOS and PFHxS among male adults. Self-reported thyroid disease was more common among women with higher levels of PFNA concentrations, whereas all other PFAS were not associated with thyroid diseases regardless of sex or age. CONCLUSIONS: Overall there is no evidence of an association between TSH and PFAS. However, some results are suggestive of a possible inverse association of TSH with PFOA, PFOS and PFHxS among adult males.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 12_ODS3_hazardous_contamination / 2_ODS3 Base de dados: MEDLINE Assunto principal: Água Potável / Tireotropina / Ácidos Alcanossulfônicos / Poluentes Ambientais / Fluorocarbonos Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male / Pregnancy País/Região como assunto: Europa Idioma: En Revista: Environ Res Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 12_ODS3_hazardous_contamination / 2_ODS3 Base de dados: MEDLINE Assunto principal: Água Potável / Tireotropina / Ácidos Alcanossulfônicos / Poluentes Ambientais / Fluorocarbonos Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male / Pregnancy País/Região como assunto: Europa Idioma: En Revista: Environ Res Ano de publicação: 2022 Tipo de documento: Article