Impaired induction of ornithine decarboxylase activity following nerve crush in the streptozotocin-diabetic rat.
Diabetologia
; 30(12): 963-5, 1987 Dec.
Article
em En
| MEDLINE
| ID: mdl-3436491
ABSTRACT
Ornithine decarboxylase activity was measured in the dorsal root ganglia from crushed and uncrushed contralateral sciatic nerve of control and streptozotocin-diabetic rats. A further group of diabetic rats was treated with insulin throughout the experiment. Ornithine decarboxylase activity in ganglia from uncrushed nerves was the same in diabetic and non-diabetic rats. A significant (greater than 4-fold) increase in mean levels of ornithine decarboxylase activity 72 h after crush injury was found in ganglia from crushed nerves in non-diabetic but not in diabetic rats. The enzyme activity in ganglia from diabetic rats treated with insulin resembled that in non-diabetic rats. Twenty-four hours after crush injury, ornithine decarboxylase activity in ganglia from crushed nerves was higher in non-diabetic than in diabetic animals. This may be responsible for the delayed and defective nerve regeneration known to occur in peripheral nerve of the streptozotocin-diabetic rat.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ornitina Descarboxilase
/
Diabetes Mellitus Experimental
/
Regeneração Nervosa
Limite:
Animals
Idioma:
En
Revista:
Diabetologia
Ano de publicação:
1987
Tipo de documento:
Article