Circadian clock, carcinogenesis, chronochemotherapy connections.

Yang, Yanyan; Lindsey-Boltz, Laura A; Vaughn, Courtney M; Selby, Christopher P; Cao, Xuemei; Liu, Zhenxing; Hsu, David S; Sancar, Aziz

Yang, Yanyan; Lindsey-Boltz, Laura A; Vaughn, Courtney M; Selby, Christopher P; Cao, Xuemei; Liu, Zhenxing; Hsu, David S; Sancar, Aziz.

Afiliação

Yang Y; Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Lindsey-Boltz LA; Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Vaughn CM; Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Selby CP; Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Cao X; Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Liu Z; Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Hsu DS; Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA. Electronic address: shiaowen.hsu@duke.edu.
Sancar A; Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA. Electronic address: aziz_sancar@med.unc.edu.

J Biol Chem ; 297(3): 101068, 2021 09.

Article em En | MEDLINE | ID: mdl-34375638

Assuntos

Carcinogênese/efeitos dos fármacos; Cronofarmacocinética; Relógios Circadianos/fisiologia; Animais; Antineoplásicos/farmacocinética; Antineoplásicos/farmacologia; Proteínas CLOCK/metabolismo; Carcinogênese/genética; Carcinogênese/metabolismo; Ciclo Celular/fisiologia; Fenômenos Cronobiológicos; Relógios Circadianos/genética; Ritmo Circadiano/fisiologia; Cisplatino/farmacocinética; Cisplatino/farmacologia; Criptocromos/genética; Criptocromos/metabolismo; Dano ao DNA/efeitos dos fármacos; Reparo do DNA/efeitos dos fármacos; Humanos; Camundongos; Neoplasias/genética; Transcrição Gênica/efeitos dos fármacos; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

XR-seq; cisplatin; colorectal cancer; cryptochrome; nucleotide excision repair; transcriptiontranslation feedback loop; xenografts

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Relógios Circadianos / Carcinogênese / Cronofarmacocinética Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2021 Tipo de documento: Article

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