[Morphological characteristics of the uterine reaction of androgenized rats in the neonatal period to the administration of sex steroids]. / Morfologicheskie kharakteristiki reaktsii matki neonatal'no androgenizirovannykh krys na vvedenie polovykh steroidov.

ABSTRACT

In female rats subjected to early neonatal androgenization (50 micrograms of testosterone propionate) the uterus at the age of maturity is of normal sizes and mass whereas its hydro-structure is substantially changed the content of stromal elements is increased and the number of glands in the endometrium is decreased. The endometrium of androgenized female rats is not sensitive to progesterone influence manifested in the absence of the collagenolytic effect of progesterone and the stimulation of uterine gland formation. It may determine stable sterility of neonatally androgenized female rats after restoration of ovulation in them.