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High-Strength and Nonfouling Zwitterionic Triple-Network Hydrogel in Saline Environments.
Li, Xiaohui; Tang, Chenjue; Liu, Di; Yuan, Zhefan; Hung, Hsiang-Chieh; Luozhong, Sijin; Gu, Wenchao; Wu, Kan; Jiang, Shaoyi.
Afiliação
  • Li X; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 14853, USA.
  • Tang C; School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin, 300350, China.
  • Liu D; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 14853, USA.
  • Yuan Z; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 14853, USA.
  • Hung HC; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 14853, USA.
  • Luozhong S; Department of Chemical Engineering, University of Washington, Seattle, WA, 98195, USA.
  • Gu W; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 14853, USA.
  • Wu K; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 14853, USA.
  • Jiang S; Department of Chemical Engineering, University of Washington, Seattle, WA, 98195, USA.
Adv Mater ; 33(39): e2102479, 2021 Oct.
Article em En | MEDLINE | ID: mdl-34387405
ABSTRACT
Zwitterionic hydrogels have received great attention due to their excellent nonfouling and biocompatible properties, but they suffer from weak mechanical strength in the saline environments important for biomedical and engineering applications due to the "anti-polyelectrolyte" effect. Conventional strategies to introduce hydrophobic or non-zwitterionic components to increase mechanical strength compromise their nonfouling properties. Here, a highly effective strategy is reported to achieve both high mechanical strength and excellent nonfouling properties by constructing a pure zwitterionic triple-network (ZTN) hydrogel. The strong electrostatic interaction and network entanglement within the triple-network structure can effectively dissipate energy to toughen the hydrogel and achieve high strength, toughness, and stiffness in saline environments (compressive fracture stress 18.2 ± 1.4 MPa, toughness 1.62 ± 0.03 MJ m-3 , and modulus 0.66 ± 0.03 MPa in seawater environments). Moreover, the ZTN hydrogel is shown to strongly resist the attachment of proteins, bacteria, and cells. The results provide a fundamental understanding to guide the design of tough nonfouling zwitterionic hydrogels for a broad range of applications.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Adv Mater Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Adv Mater Ano de publicação: 2021 Tipo de documento: Article