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Modular design principle based on compartmental drug delivery systems.
Eleftheriadis, Georgios K; Genina, Natalja; Boetker, Johan; Rantanen, Jukka.
Afiliação
  • Eleftheriadis GK; Department of Pharmacy, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece.
  • Genina N; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark.
  • Boetker J; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark.
  • Rantanen J; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark. Electronic address: jukka.rantanen@sund.ku.dk.
Adv Drug Deliv Rev ; 178: 113921, 2021 11.
Article em En | MEDLINE | ID: mdl-34390776
The current manufacturing solutions for oral solid dosage forms are fundamentally based on technologies from the 19th century. This approach is well suited for mass production of one-size-fits-all products; however, it does not allow for a straight-forward personalization and mass customization of the pharmaceutical end-product. In order to provide better therapies to the patients, a need for innovative manufacturing concepts and product design principles has been rising. Additive manufacturing opens up a possibility for compartmentalization of drug products, including design of spatially separated multidrug and functional excipient compartments. This compartmentalized solution can be further expanded to modular design thinking. Modular design is referring to combination of building blocks containing a given amount of drug compound(s) and related functional excipients into a larger final product. Implementation of modular design principles is paving the way for implementing the emerging personalization potential within health sciences by designing compartmental and reactive product structures that can be manufactured based on the individual needs of each patient. This review will introduce the existing compartmentalized product design principles and discuss the integration of these into edible electronics allowing for innovative control of drug release.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Desenho de Fármacos / Sistemas de Liberação de Medicamentos Limite: Humans Idioma: En Revista: Adv Drug Deliv Rev Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Desenho de Fármacos / Sistemas de Liberação de Medicamentos Limite: Humans Idioma: En Revista: Adv Drug Deliv Rev Ano de publicação: 2021 Tipo de documento: Article