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Cross-validation of a high-performance liquid chromatography nevirapine plasma assay in a resource-limited setting in Zimbabwe.
Makita-Chingombe, Faithful; Podany, Anthony T; Mykris, Timothy; Muzambi, Farai; Browne, Richard W; Ocque, Andrew J; DiFrancesco, Robin; Winchester, Lee C; Fletcher, Courtney V; Mudzviti, Tinashe; Maponga, Charles C; Morse, Gene D.
Afiliação
  • Makita-Chingombe F; International Pharmacology Specialty Laboratory, School of Pharmacy, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.
  • Podany AT; Antiviral Pharmacology Laboratory, University of Nebraska Medical Center, Omaha, Nebraska, United States.
  • Mykris T; Antiviral Pharmacology Laboratory, University of Nebraska Medical Center, Omaha, Nebraska, United States.
  • Muzambi F; International Pharmacology Specialty Laboratory, School of Pharmacy, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.
  • Browne RW; Translational Pharmacology Research Core, Center for Integrated Global Biomedical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, United States.
  • Ocque AJ; Translational Pharmacology Research Core, Center for Integrated Global Biomedical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, United States.
  • DiFrancesco R; Translational Pharmacology Research Core, Center for Integrated Global Biomedical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, United States.
  • Winchester LC; Antiviral Pharmacology Laboratory, University of Nebraska Medical Center, Omaha, Nebraska, United States.
  • Fletcher CV; Antiviral Pharmacology Laboratory, University of Nebraska Medical Center, Omaha, Nebraska, United States.
  • Mudzviti T; International Pharmacology Specialty Laboratory, School of Pharmacy, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.
  • Maponga CC; International Pharmacology Specialty Laboratory, School of Pharmacy, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.
  • Morse GD; Translational Pharmacology Research Core, Center for Integrated Global Biomedical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, United States.
Afr J Lab Med ; 10(1): 1264, 2021.
Article em En | MEDLINE | ID: mdl-34395199
ABSTRACT
An international HIV pharmacology specialty laboratory (PSL) was established at the University of Zimbabwe to increase bioanalytical and investigator capacities. Quantitation of plasma nevirapine in samples from the AIDS Clinical Trials Group protocol 5279 was compared between the University of Nebraska Medical Center PSL and the University of Zimbabwe PSL. Both PSLs employed internally developed methods utilising reverse-phase high-performance liquid chromatography with ultraviolet detection. Eighty-seven percent of the cross-validation results exhibited ± 20% difference.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Guideline Idioma: En Revista: Afr J Lab Med Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Guideline Idioma: En Revista: Afr J Lab Med Ano de publicação: 2021 Tipo de documento: Article