A physiologically based pharmacokinetic (PBPK) model to describe organ distribution of <sup>68</sup>Ga-DOTATATE in patients without neuroendocrine tumors.

Siebinga, H; de Wit-van der Veen, B J; Beijnen, J H; Stokkel, M P M; Dorlo, T P C; Huitema, A D R; Hendrikx, J J M A

A physiologically based pharmacokinetic (PBPK) model to describe organ distribution of ⁶⁸Ga-DOTATATE in patients without neuroendocrine tumors.

Siebinga, H; de Wit-van der Veen, B J; Beijnen, J H; Stokkel, M P M; Dorlo, T P C; Huitema, A D R; Hendrikx, J J M A.

Afiliação

Siebinga H; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
de Wit-van der Veen BJ; Department of Nuclear Medicine, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Beijnen JH; Department of Nuclear Medicine, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Stokkel MPM; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Dorlo TPC; Department of Nuclear Medicine, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Huitema ADR; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Hendrikx JJMA; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

EJNMMI Res ; 11(1): 73, 2021 Aug 16.

Article em En | MEDLINE | ID: mdl-34398356

Palavras-chave

68Ga-DOTATATE; PBPK modeling; PRRT; Peptide amount; SSTR2; Whole-body distribution

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: EJNMMI Res Ano de publicação: 2021 Tipo de documento: Article

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