Taspine is a natural product that suppresses P2X4 receptor activity via phosphoinositide 3-kinase inhibition.

Nadzirin, Izzuddin Bin; Fortuny-Gomez, Anna; Ngum, Neville; Richards, David; Ali, Seema; Searcey, Mark; Fountain, Samuel J

Nadzirin, Izzuddin Bin; Fortuny-Gomez, Anna; Ngum, Neville; Richards, David; Ali, Seema; Searcey, Mark; Fountain, Samuel J.

Afiliação

Nadzirin IB; Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich, UK.
Fortuny-Gomez A; Kulliyyah of Allied Health Sciences, International Islamic University Malaysia, Kuantan Campus, Kuantan, Malaysia.
Ngum N; Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich, UK.
Richards D; Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich, UK.
Ali S; Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich, UK.
Searcey M; Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich, UK.
Fountain SJ; School of Pharmacy, University of East Anglia, Norwich, UK.

Br J Pharmacol ; 178(24): 4859-4872, 2021 12.

Article em En | MEDLINE | ID: mdl-34398973

Assuntos

Produtos Biológicos; Receptores Purinérgicos P2X4; Trifosfato de Adenosina; Alcaloides; Animais; Camundongos; Fosfatidilinositol 3-Quinase; Fosfatidilinositol 3-Quinases; Receptores Purinérgicos P2X7

Palavras-chave

P2X receptor; ion channel; natural product; purinergic

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Receptores Purinérgicos P2X4 Limite: Animals Idioma: En Revista: Br J Pharmacol Ano de publicação: 2021 Tipo de documento: Article

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