Helicobacters and cancer, not only gastric cancer?
Semin Cancer Biol
; 86(Pt 2): 1138-1154, 2022 11.
Article
em En
| MEDLINE
| ID: mdl-34425210
ABSTRACT
The Helicobacter genus actually comprises 46 validly published species divided into two main clades gastric and enterohepatic Helicobacters. These bacteria colonize alternative sites of the digestive system in animals and humans, and contribute to inflammation and cancers. In humans, Helicobacter infection is mainly related to H. pylori, a gastric pathogen infecting more than half of the world's population, leading to chronic inflammation of the gastric mucosa that can evolve into two types of gastric cancers gastric adenocarcinomas and gastric MALT lymphoma. In addition, H. pylori but also non-H. pylori Helicobacter infection has been associated with many extra-gastric malignancies. This review focuses on H. pylori and its role in gastric cancers and extra-gastric diseases, as well as malignancies induced by non-H. pylori Helicobacters. Their different virulence factors and their involvement in carcinogenesis is discussed. This review highlights the importance of both gastric and enterohepatic Helicobacters in gastrointestinal and liver cancers.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
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Helicobacter pylori
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Infecções por Helicobacter
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Helicobacter
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Linfoma de Zona Marginal Tipo Células B
Tipo de estudo:
Etiology_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Semin Cancer Biol
Ano de publicação:
2022
Tipo de documento:
Article