Design, synthesis, and pharmacological evaluation of sinomenine derivatives on rings A and C: Novel compounds screening for aplastic anemia targeting on cytotoxic T lymphocyte.

Zhang, Ziqian; Wang, Hongjian; Yuan, Jiqiao; Li, Xuyu; Fang, Nan; Lin, Mingbao; Hou, Qi; Ji, Tengfei

Zhang, Ziqian; Wang, Hongjian; Yuan, Jiqiao; Li, Xuyu; Fang, Nan; Lin, Mingbao; Hou, Qi; Ji, Tengfei.

Afiliação

Zhang Z; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.
Wang H; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.
Yuan J; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.
Li X; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.
Fang N; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.
Lin M; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China. Electronic address: mingbaolin@imm.cams.cn.
Hou Q; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China. Electronic address: houq@imm.ac.cn.
Ji T; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China. Electronic address: jitf@imm.ac.cn.

Eur J Med Chem ; 225: 113791, 2021 Dec 05.

Article em En | MEDLINE | ID: mdl-34450495

Assuntos

Anemia Aplástica/tratamento farmacológico; Antirreumáticos/farmacologia; Desenho de Fármacos; Morfinanos/farmacologia; Linfócitos T Citotóxicos/efeitos dos fármacos; Anemia Aplástica/imunologia; Animais; Antirreumáticos/síntese química; Antirreumáticos/química; Células Cultivadas; Relação Dose-Resposta a Droga; Masculino; Camundongos; Camundongos Endogâmicos; Estrutura Molecular; Morfinanos/síntese química; Morfinanos/química; Relação Estrutura-Atividade; Linfócitos T Citotóxicos/imunologia

Palavras-chave

Aplastic anemia; Cytotoxic T lymphocyte; Derivatives; Sinomenine

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T Citotóxicos / Desenho de Fármacos / Antirreumáticos / Anemia Aplástica / Morfinanos Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Animals Idioma: En Revista: Eur J Med Chem Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google