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Motor Skills: Recruitment of Kinesins, Myosins and Dynein during Assembly and Egress of Alphaherpesviruses.
Wilson, Duncan W.
Afiliação
  • Wilson DW; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Viruses ; 13(8)2021 08 17.
Article em En | MEDLINE | ID: mdl-34452486
The alphaherpesviruses are pathogens of the mammalian nervous system. Initial infection is commonly at mucosal epithelia, followed by spread to, and establishment of latency in, the peripheral nervous system. During productive infection, viral gene expression, replication of the dsDNA genome, capsid assembly and genome packaging take place in the infected cell nucleus, after which mature nucleocapsids emerge into the cytoplasm. Capsids must then travel to their site of envelopment at cytoplasmic organelles, and enveloped virions need to reach the cell surface for release and spread. Transport at each of these steps requires movement of alphaherpesvirus particles through a crowded and viscous cytoplasm, and for distances ranging from several microns in epithelial cells, to millimeters or even meters during egress from neurons. To solve this challenging problem alphaherpesviruses, and their assembly intermediates, exploit microtubule- and actin-dependent cellular motors. This review focuses upon the mechanisms used by alphaherpesviruses to recruit kinesin, myosin and dynein motors during assembly and egress.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Miosinas / Cinesinas / Dineínas / Alphaherpesvirinae / Montagem de Vírus / Liberação de Vírus Limite: Humans Idioma: En Revista: Viruses Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Miosinas / Cinesinas / Dineínas / Alphaherpesvirinae / Montagem de Vírus / Liberação de Vírus Limite: Humans Idioma: En Revista: Viruses Ano de publicação: 2021 Tipo de documento: Article