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Penalized regression calibration: A method for the prediction of survival outcomes using complex longitudinal and high-dimensional data.
Signorelli, Mirko; Spitali, Pietro; Szigyarto, Cristina Al-Khalili; Tsonaka, Roula.
Afiliação
  • Signorelli M; Mathematical Institute, Leiden University, Leiden, The Netherlands.
  • Spitali P; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
  • Szigyarto CA; Department of Protein Science, KTH-Royal Institute of Technology, Stockholm, Sweden.
  • Tsonaka R; Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.
Stat Med ; 40(27): 6178-6196, 2021 11 30.
Article em En | MEDLINE | ID: mdl-34464990
ABSTRACT
Longitudinal and high-dimensional measurements have become increasingly common in biomedical research. However, methods to predict survival outcomes using covariates that are both longitudinal and high-dimensional are currently missing. In this article, we propose penalized regression calibration (PRC), a method that can be employed to predict survival in such situations. PRC comprises three modeling

steps:

First, the trajectories described by the longitudinal predictors are flexibly modeled through the specification of multivariate mixed effects models. Second, subject-specific summaries of the longitudinal trajectories are derived from the fitted mixed models. Third, the time to event outcome is predicted using the subject-specific summaries as covariates in a penalized Cox model. To ensure a proper internal validation of the fitted PRC models, we furthermore develop a cluster bootstrap optimism correction procedure that allows to correct for the optimistic bias of apparent measures of predictiveness. PRC and the CBOCP are implemented in the R package pencal, available from CRAN. After studying the behavior of PRC via simulations, we conclude by illustrating an application of PRC to data from an observational study that involved patients affected by Duchenne muscular dystrophy, where the goal is predict time to loss of ambulation using longitudinal blood biomarkers.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Calibragem Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Stat Med Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Calibragem Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Stat Med Ano de publicação: 2021 Tipo de documento: Article