CARS senses cysteine deprivation to activate AMPK for cell survival.

Yuan, Mengqiu; Yan, Ronghui; Zhang, Yi; Qiu, Yue; Jiang, Zetan; Liu, Haiying; Wang, Ying; Sun, Linchong; Zhang, Huafeng; Gao, Ping

Yuan, Mengqiu; Yan, Ronghui; Zhang, Yi; Qiu, Yue; Jiang, Zetan; Liu, Haiying; Wang, Ying; Sun, Linchong; Zhang, Huafeng; Gao, Ping.

Afiliação

Yuan M; CAS Key Laboratory of Innate Immunity and Chronic Disease, Hefei National Laboratory for Physical Sciences at Microscale, Innovation Center for Cell Signaling Network, School of Life Science, University of Science and Technology of China, Hefei, China.
Yan R; CAS Key Laboratory of Innate Immunity and Chronic Disease, Hefei National Laboratory for Physical Sciences at Microscale, Innovation Center for Cell Signaling Network, School of Life Science, University of Science and Technology of China, Hefei, China.
Zhang Y; Guangzhou First People's Hospital, School of Medicine, Institutes for Life Sciences, South China University of Technology, Guangzhou, China.
Qiu Y; Guangzhou First People's Hospital, School of Medicine, Institutes for Life Sciences, South China University of Technology, Guangzhou, China.
Jiang Z; CAS Key Laboratory of Innate Immunity and Chronic Disease, Hefei National Laboratory for Physical Sciences at Microscale, Innovation Center for Cell Signaling Network, School of Life Science, University of Science and Technology of China, Hefei, China.
Liu H; CAS Key Laboratory of Innate Immunity and Chronic Disease, Hefei National Laboratory for Physical Sciences at Microscale, Innovation Center for Cell Signaling Network, School of Life Science, University of Science and Technology of China, Hefei, China.
Wang Y; Guangzhou First People's Hospital, School of Medicine, Institutes for Life Sciences, South China University of Technology, Guangzhou, China.
Sun L; Guangzhou First People's Hospital, School of Medicine, Institutes for Life Sciences, South China University of Technology, Guangzhou, China.
Zhang H; CAS Key Laboratory of Innate Immunity and Chronic Disease, Hefei National Laboratory for Physical Sciences at Microscale, Innovation Center for Cell Signaling Network, School of Life Science, University of Science and Technology of China, Hefei, China.
Gao P; CAS Key Laboratory of Innate Immunity and Chronic Disease, Hefei National Laboratory for Physical Sciences at Microscale, Innovation Center for Cell Signaling Network, School of Life Science, University of Science and Technology of China, Hefei, China.

EMBO J ; 40(21): e108028, 2021 11 02.

Article em En | MEDLINE | ID: mdl-34472622

Assuntos

Proteínas Quinases Ativadas por AMP/genética; Adaptação Fisiológica/genética; Aminoacil-tRNA Sintetases/genética; Quinase da Proteína Quinase Dependente de Cálcio-Calmodulina/genética; Cisteína/deficiência; Proteínas Quinases Ativadas por AMP/antagonistas & inibidores; Proteínas Quinases Ativadas por AMP/metabolismo; Acetil-CoA Carboxilase/genética; Acetil-CoA Carboxilase/metabolismo; Trifosfato de Adenosina/metabolismo; Aminoacil-tRNA Sintetases/metabolismo; Quinase da Proteína Quinase Dependente de Cálcio-Calmodulina/metabolismo; Linhagem Celular Tumoral; Sobrevivência Celular/genética; Células Epiteliais/citologia; Células Epiteliais/metabolismo; Ácidos Graxos/metabolismo; Regulação da Expressão Gênica; Células HEK293; Humanos; Ligação Proteica; RNA Interferente Pequeno/genética; RNA Interferente Pequeno/metabolismo; Proteína Regulatória Associada a mTOR/genética; Proteína Regulatória Associada a mTOR/metabolismo; Transdução de Sinais

Palavras-chave

AMPK; CARS; cell survival; cyst(e)ine

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adaptação Fisiológica / Cisteína / Quinase da Proteína Quinase Dependente de Cálcio-Calmodulina / Proteínas Quinases Ativadas por AMP / Aminoacil-tRNA Sintetases Limite: Humans Idioma: En Revista: EMBO J Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google