Flavanols and Flavanes from Crinum asiaticum and Their Effects on LPS Signaling Pathway Through the Inhibition of NF-κB Activation.
Planta Med
; 88(11): 913-920, 2022 Sep.
Article
em En
| MEDLINE
| ID: mdl-34474490
ABSTRACT
Three new flavanols, (2R,3S)-7-methoxy-flavan-3-ol (1 ), (2R,3S)-7-hydroxy-flavan-3-ol (2 ), and (2R,3S)-2'-hydroxy-7-methoxy-flavan-3-ol (3 ), together with two known flavans (4 and 5 ), were isolated from the chloroform extract of Crinum asiaticum. Their structures were elucidated by various spectroscopic methods, including 1D and 2D NMR, HR-ESI-MS, and CD data. The isolated compounds 1 and 3 -5 showed inhibitory activity toward LPS-induced nitric oxide (NO) production. Further investigation of the NF-κB pathway mechanisms indicated that 1 and 3 -5 inhibited the LPS-induced IL-6 production and p65 subunit phosphorylation of NF-κB in RAW264.7 cells, with an effective dose of 10 µM.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Flavonoides
/
NF-kappa B
/
Crinum
Limite:
Animals
Idioma:
En
Revista:
Planta Med
Ano de publicação:
2022
Tipo de documento:
Article