The comparison of tracheostomy and translaryngeal intubation regarding free radical formation and pulmonary effects.
Ulus Travma Acil Cerrahi Derg
; 27(5): 491-496, 2021 Sep.
Article
em En
| MEDLINE
| ID: mdl-34476792
ABSTRACT
BACKGROUND:
Our aim in this study was to compare the blood gas changes, the malondialdehyde (MDA) and endogenous antioxidant glutathione (GSH) levels in blood and lung tissues after ischemia/reperfusion, the histopathological damage in lung tissue in rats provided respiratory support with mechanical ventilation after translaryngeal intubation and tracheostomy.METHODS:
Group 1 rats were provided mechanical ventilator support after translaryngeal intubation, Group 2 mechanical ventilator support after tracheostomy, and Group 3 was the control group where rats were only anesthetized. Three groups were compared for blood gas changes, MDA, GSH, and histopathological changes.RESULTS:
Blood gas evaluation showed a more marked increase in pO2 values and decline in pCO2 values in Group 2 than Group 1 (p<0.05), and higher serum MDA levels in Group 1 than Group 2 (p<0.05). Tissue GSH levels in Groups 1 and 2 were higher than the control group, but this difference was not statistically significant (p>0.05). In terms of histopathological scoring, the damage score in Group 1 was higher than in Group 2 (p<0.05).CONCLUSION:
This is the first study to show tracheostomy to be more advantageous than translaryngeal intubation in terms of blood gases, ischemia/reperfusion damage, and structural changes in the lung tissue.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Traqueostomia
/
Traumatismo por Reperfusão
Limite:
Animals
Idioma:
En
Revista:
Ulus Travma Acil Cerrahi Derg
Ano de publicação:
2021
Tipo de documento:
Article