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Cell-specific activation of gemcitabine by endogenous H2S stimulation and tracking through simultaneous fluorescence turn-on.
Maiti, Mrinmoy; Yoon, Shin A; Cha, Yujin; Athul, K K; Bhuniya, Sankarprasad; Lee, Min Hee.
Afiliação
  • Maiti M; Department of Science, School of Engineering, Amrita Vishwa Vidyapeetham, Coimbatore, 641112, India.
  • Yoon SA; Department of Chemistry, Sookmyung Women's University, Seoul 04310, Korea. minheelee@sookmyung.ac.kr.
  • Cha Y; Department of Chemistry, Sookmyung Women's University, Seoul 04310, Korea. minheelee@sookmyung.ac.kr.
  • Athul KK; Centre for Interdisciplinary Science, JIS Institute of Advanced Studies and Research, JIS University, Salt Lake, Kolkata, 700091, India. spbhuniya@jisiasr.org.
  • Bhuniya S; Centre for Interdisciplinary Science, JIS Institute of Advanced Studies and Research, JIS University, Salt Lake, Kolkata, 700091, India. spbhuniya@jisiasr.org.
  • Lee MH; Department of Chemistry, Sookmyung Women's University, Seoul 04310, Korea. minheelee@sookmyung.ac.kr.
Chem Commun (Camb) ; 57(75): 9614-9617, 2021 Sep 21.
Article em En | MEDLINE | ID: mdl-34486009
ABSTRACT
The endogenous H2S-driven theranostic H2S-Gem has been invented. The theranostic prodrug H2S-Gem is selectively activated in cancer cells, releasing active gemcitabine with a simultaneous fluorescence turn-on. H2S-Gem selectively inhibited cancer cell growth compared to the mother chemotherapeutic gemcitabine. Overall, it is a unique protocol for tracking and transporting chemotherapeutic agents to tumor areas without the guidance of tumor-directive ligands.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pró-Fármacos / Desoxicitidina / Sulfeto de Hidrogênio / Antimetabólitos Antineoplásicos Limite: Humans Idioma: En Revista: Chem Commun (Camb) Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pró-Fármacos / Desoxicitidina / Sulfeto de Hidrogênio / Antimetabólitos Antineoplásicos Limite: Humans Idioma: En Revista: Chem Commun (Camb) Ano de publicação: 2021 Tipo de documento: Article