Autophagy Dysfunction as a Phenotypic Readout in hiPSC-Derived Neuronal Cell Models of Neurodegenerative Diseases.

Sun, Congxin; Rosenstock, Tatiana R; Cohen, Malkiel A; Sarkar, Sovan

Sun, Congxin; Rosenstock, Tatiana R; Cohen, Malkiel A; Sarkar, Sovan.

Afiliação

Sun C; Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Rosenstock TR; Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Cohen MA; Department of Pharmacology, University of São Paulo, São Paulo, Brazil.
Sarkar S; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.

Methods Mol Biol ; 2549: 103-136, 2022.

Article em En | MEDLINE | ID: mdl-34490597

Assuntos

Células-Tronco Pluripotentes Induzidas; Doenças Neurodegenerativas; Autofagia; Homeostase; Humanos; Células-Tronco Pluripotentes Induzidas/metabolismo; Doenças Neurodegenerativas/metabolismo; Neurônios/metabolismo

Palavras-chave

Autophagosome; Autophagy; Autophagy dysfunction; Autophagy inducer; Autophagy substrate; Human induced pluripotent stem cells; LC3; Neurodegenerative disease; Neuronal differentiation; hiPSC-derived neurons; p62

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Neurodegenerativas / Células-Tronco Pluripotentes Induzidas Limite: Humans Idioma: En Revista: Methods Mol Biol Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google