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Renoprotective effect of N-acetylcysteine depends upon the severity of the ischemia reperfusion injury.
Watanabe, M; Borges, F T; Pessoa, E A; Fonseca, C D; Fernandes, S M; Drew, R C; Volpini, R A; Vattimo, M F F.
Afiliação
  • Watanabe M; Laboratório Experimental de Modelos Animais, Escola de Enfermagem, Universidade de São Paulo, São Paulo, SP, Brasil.
  • Borges FT; Divisão de Nefrologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
  • Pessoa EA; Divisão de Nefrologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
  • Fonseca CD; Escola Paulista de Enfermagem, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
  • Fernandes SM; Laboratório Experimental de Modelos Animais, Escola de Enfermagem, Universidade de São Paulo, São Paulo, SP, Brasil.
  • Drew RC; Department of Exercise and Health Sciences, College of Nursing and Health Sciences, University of Massachusetts Boston, Boston, MA, USA.
  • Volpini RA; Departamento de Nefrologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
  • Vattimo MFF; Laboratório Experimental de Modelos Animais, Escola de Enfermagem, Universidade de São Paulo, São Paulo, SP, Brasil.
Braz J Med Biol Res ; 54(11): e9941, 2021.
Article em En | MEDLINE | ID: mdl-34495252
Acute kidney injury (AKI) is a common complication in seriously ill patients, while renal ischemia-reperfusion (I/R) injury is the most frequent event in this oxidative renal injury. N-acetylcysteine (NAC) is a small molecule containing a thiol group that has antioxidant properties, promoting detoxification and acting directly as a free radical scavenger. In this study, the protective effect of NAC was investigated in short-term (30 min) and long-term (45 min) ischemic AKI. This was achieved via clamping of the renal artery for 30 or 45 min in Wistar rats to induce I/R injury. AKI worsened with a longer period of ischemia (45 compared to 30 min) due to probable irreversible damage. Preconditioning with NAC in short-term ischemia improved renal blood flow and increased creatinine clearance by reducing oxidative metabolites and increasing antioxidant capacity. Otherwise, NAC did not change these parameters in the long-term ischemia. Therefore, this study demonstrated that the period of ischemia determines the severity of the AKI, and NAC presented antioxidant effects in short-term ischemia but not in long-term ischemia, confirming that there is a possible therapeutic window for its renoprotective effect.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão / Injúria Renal Aguda Limite: Animals / Humans Idioma: En Revista: Braz J Med Biol Res Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão / Injúria Renal Aguda Limite: Animals / Humans Idioma: En Revista: Braz J Med Biol Res Ano de publicação: 2021 Tipo de documento: Article