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Developmental dysregulation of excitatory-to-inhibitory GABA-polarity switch may underlie schizophrenia pathology: A monozygotic-twin discordant case analysis in human iPS cell-derived neurons.
Toritsuka, Michihiro; Yoshino, Hiroki; Makinodan, Manabu; Ikawa, Daisuke; Kimoto, Sohei; Yamamuro, Kazuhiko; Okamura, Kazuya; Akamatsu, Wado; Okada, Yohei; Matsumoto, Takuya; Hashimoto, Kazumichi; Ogawa, Yoichi; Saito, Yasuhiko; Watanabe, Kyosuke; Aoki, Chieko; Takada, Ryohei; Fukami, Shin-Ichi; Hamano-Iwasa, Kaori; Okano, Hideyuki; Kishimoto, Toshifumi.
Afiliação
  • Toritsuka M; Department of Psychiatry, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan. Electronic address: tori-m@naramed-u.ac.jp.
  • Yoshino H; Department of Psychiatry, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
  • Makinodan M; Department of Psychiatry, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
  • Ikawa D; Department of Psychiatry, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan; Sakai Municipal Mental Health Center, 4-3-1 Asahigaoka-naka-machi, Sakai-ku, Sakai-shi, Osaka, 590-0808, Japan.
  • Kimoto S; Department of Psychiatry, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
  • Yamamuro K; Department of Psychiatry, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
  • Okamura K; Department of Psychiatry, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
  • Akamatsu W; Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan; Center for Genomic and Regenerative Medicine, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8431, Japan.
  • Okada Y; Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan; Department of Neurology, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
  • Matsumoto T; Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
  • Hashimoto K; Department of Psychiatry, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan; Department of Psychiatry, Tenri Hospital Shirakawa Branch, 604 Iwaya-cho, Tenri, Nara, 632-0003, Japan.
  • Ogawa Y; Department of Neurophysiology, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.
  • Saito Y; Department of Neurophysiology, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.
  • Watanabe K; Department of Psychiatry, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
  • Aoki C; Department of Psychiatry, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
  • Takada R; Department of Psychiatry, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
  • Fukami SI; Department of Psychiatry, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
  • Hamano-Iwasa K; Department of Psychiatry, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
  • Okano H; Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
  • Kishimoto T; Department of Psychiatry, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
Neurochem Int ; 150: 105179, 2021 11.
Article em En | MEDLINE | ID: mdl-34500023
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Gêmeos Monozigóticos / Simportadores / Células-Tronco Pluripotentes Induzidas / Neurônios GABAérgicos / Neurônios Limite: Adult / Humans / Male Idioma: En Revista: Neurochem Int Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Gêmeos Monozigóticos / Simportadores / Células-Tronco Pluripotentes Induzidas / Neurônios GABAérgicos / Neurônios Limite: Adult / Humans / Male Idioma: En Revista: Neurochem Int Ano de publicação: 2021 Tipo de documento: Article