Total Syntheses of (+)-Peniciketals A-B and (-)-Diocollettines A Exploiting a Photoisomerization/Cyclization Union Protocol.
J Org Chem
; 86(19): 13583-13597, 2021 10 01.
Article
em En
| MEDLINE
| ID: mdl-34510901
ABSTRACT
A late-stage photoisomerization/cyclization union tactic, in conjunction with Type I Anion Relay Chemistry (ARC), permits enantioselective total syntheses and then biological evaluation of (+)-peniciketals A and B. The photochemical protocol was further showcased by an efficient three-step construction of the architecturally complex polycyclic skeleton found in (-)-diocollettines A. The mechanism and diastereoselectivity of the photochemical protocol have also been explored by both experiment and density functional theory calculations.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ciclização
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2021
Tipo de documento:
Article