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Electro-Oxidative C-N Bond Formation through Azolation of Indole Derivatives: An Access to 3-Substituent-2-(Azol-1-yl)indoles.
Zhou, Naifu; Zhao, Junhao; Sun, Chengbo; Lai, Yuqin; Ruan, Zhixiong; Feng, Pengju.
Afiliação
  • Zhou N; Department of Chemistry and Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Jinan University, Guangzhou 510632, China.
  • Zhao J; Department of Chemistry and Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Jinan University, Guangzhou 510632, China.
  • Sun C; Department of Chemistry and Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Jinan University, Guangzhou 510632, China.
  • Lai Y; Department of Chemistry and Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Jinan University, Guangzhou 510632, China.
  • Ruan Z; Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Science, and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, China.
  • Feng P; Department of Chemistry and Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Jinan University, Guangzhou 510632, China.
J Org Chem ; 86(22): 16059-16067, 2021 11 19.
Article em En | MEDLINE | ID: mdl-34520191
ABSTRACT
A practical protocol to synthesize 3-substituent-2-(azol-1-yl)indole derivatives has been developed via an electrochemical oxidative cross coupling process under mild conditions. This electro-oxidative C-N bond formation strategy tolerates a range of functional groups and is amenable to gram scale synthesis. Moreover, this method was applied to the late-stage functionalization of bioactive molecules.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Danazol / Indóis Tipo de estudo: Guideline Idioma: En Revista: J Org Chem Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Danazol / Indóis Tipo de estudo: Guideline Idioma: En Revista: J Org Chem Ano de publicação: 2021 Tipo de documento: Article